There are currently several projects under consideration at various stages in the planning process. A selection of these are:
SUNRRISE Trial
Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy. This is a randomised controlled trial being run nationally and internationally, and likely to begin recruiting late 2019.
Protocol here: www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/coloproctology/SUNRRISE/index.aspx
RECON
REspiratory ComplicatiOns after abdomiNal Surgery. Exploring the incidence of PPCs following major abdominal and incisional hernia surgery and Secondary establish risk factors for development of PPCs.
Info here: https://starsurg.org/recon-project-18-19/
DAMASCUS Study
DAMASCUS (Diverticular Abscess Management: A Snapshot Collaborative aUdit Study) is an international, prospective study aiming to investigate the variations in the management of patients with diverticular abscess and whether these variations are associated with short term clinical outcomes at 30 days or with readmission or re-intervention rates over the subsequent 6 months.
Protocol here: www.acpgbi.org.uk/news/damascus-study-in-the-uk/
MBP+ / AMBRACE
This is a four-arm open label randomised controlled trial of pre-operative mechanical bowel preparation (MBP) +/- oral antibiotic prophylaxis (Abx) in patients undergoing elective colectomy for cancer. There is international equipoise presently between whether either or both pre-operative interventions has an impact on surgical site infection and anastomotic leak in patients undergoing colectomy for colon cancer.11-13 Patients will randomised to one of the following arms: Group 1: MBP only, Group 2: Abx only, Group 3: MBP and Abx, Group 4: Nothing. The primary outcome will be surgical site infection, and secondary outcomes will include anastomotic leak, colonic microbiome analysis, and local / distant colon cancer recurrence. This study will need to be a large multi-centre collaboration, and a research assistant will be crucial to facilitate this.
Post-operative ileus novel treatments
After completion of the STIMULAX Trial, we hope to establish the standard of care for post-operative return of bowel function, and use this new baseline to test novel treatments with the hope of improving this even further. Several novel drugs are currently under consideration.
Leak Check 2 / Double Check
If Leak Check identifies modifiable risk factors for anastomotic leak (likely), then a followup international study is in the planning stages to test whether modification of these factors in the pre-operative and intra-operative stage could reduce the incidence of post-operative anastomotic leak.
SUNRRISE Trial
Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy. This is a randomised controlled trial being run nationally and internationally, and likely to begin recruiting late 2019.
Protocol here: www.birmingham.ac.uk/research/activity/mds/trials/bctu/trials/coloproctology/SUNRRISE/index.aspx
RECON
REspiratory ComplicatiOns after abdomiNal Surgery. Exploring the incidence of PPCs following major abdominal and incisional hernia surgery and Secondary establish risk factors for development of PPCs.
Info here: https://starsurg.org/recon-project-18-19/
DAMASCUS Study
DAMASCUS (Diverticular Abscess Management: A Snapshot Collaborative aUdit Study) is an international, prospective study aiming to investigate the variations in the management of patients with diverticular abscess and whether these variations are associated with short term clinical outcomes at 30 days or with readmission or re-intervention rates over the subsequent 6 months.
Protocol here: www.acpgbi.org.uk/news/damascus-study-in-the-uk/
MBP+ / AMBRACE
This is a four-arm open label randomised controlled trial of pre-operative mechanical bowel preparation (MBP) +/- oral antibiotic prophylaxis (Abx) in patients undergoing elective colectomy for cancer. There is international equipoise presently between whether either or both pre-operative interventions has an impact on surgical site infection and anastomotic leak in patients undergoing colectomy for colon cancer.11-13 Patients will randomised to one of the following arms: Group 1: MBP only, Group 2: Abx only, Group 3: MBP and Abx, Group 4: Nothing. The primary outcome will be surgical site infection, and secondary outcomes will include anastomotic leak, colonic microbiome analysis, and local / distant colon cancer recurrence. This study will need to be a large multi-centre collaboration, and a research assistant will be crucial to facilitate this.
Post-operative ileus novel treatments
After completion of the STIMULAX Trial, we hope to establish the standard of care for post-operative return of bowel function, and use this new baseline to test novel treatments with the hope of improving this even further. Several novel drugs are currently under consideration.
Leak Check 2 / Double Check
If Leak Check identifies modifiable risk factors for anastomotic leak (likely), then a followup international study is in the planning stages to test whether modification of these factors in the pre-operative and intra-operative stage could reduce the incidence of post-operative anastomotic leak.